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An extreme consequence is the occurrence of the rare condition named calciphylaxis. A UK tour began in 2009 and visited more than two dozen cities before ending in 2011. The original cast included Connie Fisher as Maria, Michael Praed as Captain von Trapp and Margaret Preece as the Mother Abbess. Jason Donovan assumed the role of Captain Von Trapp, and Verity Rushworth took over as Maria, in early 2011. Lesley Garrett reprised her role as Mother Abbess for the tour's final engagement in Wimbledon in October 2011.
The 1961 London production was recorded by EMI and released on the HMV label and later re-issued on CD in 1997, on the Broadway Angel label. A live televised production of the musical aired twice in December 2013 on NBC. It was directed by Beth McCarthy-Miller and Rob Ashford. Carrie Underwood starred as Maria, with Stephen Moyer as Captain von Trapp, Christian Borle as Max, Laura Benanti as Elsa, and Audra McDonald as the Mother Abbess. A production was mounted at the Open Air Theatre, Regent's Park from July to September 2013.
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The director was Vincent J. Donehue, and the choreographer was Joe Layton. The original cast included Mary Martin as Maria, Theodore Bikel as Captain Georg von Trapp, Patricia Neway as Mother Abbess, Kurt Kasznar as Max Detweiler, Marion Marlowe as Elsa Schräder, Brian Davies as Rolf and Lauri Peters as Liesl. Patricia Brooks, June Card and Tatiana Troyanos were ensemble members in the original production.

The condition of individuals with CKD, who require either of the two types of kidney replacement therapy , is referred to as the end-stage kidney disease . Hence, the start of the ESKD is practically the irreversible conclusion of the NDD-CKD. Even though the NDD-CKD status refers to the status of persons with earlier stages of CKD , people with advanced stage of CKD , who have not yet started kidney replacement therapy, are also referred to as NDD-CKD. They have also been found to reduce the risk of major cardiovascular events such as myocardial infarction, stroke, heart failure, and death from cardiovascular disease when compared to placebo in individuals with CKD.
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Apart from controlling other risk factors, the goal of therapy is to slow down or halt the progression of CKD. Control of blood pressure and treatment of the original disease are the broad principles of management. Kidney ultrasonography is useful for diagnostic and prognostic purposes in chronic kidney disease. Whether the underlying pathologic change is glomerular sclerosis, tubular atrophy, interstitial fibrosis, or inflammation, the result is often increased echogenicity of the cortex. The echogenicity of the kidney should be related to the echogenicity of either the liver or the spleen . Moreover, decreased kidney size and cortical thinning are also often seen and especially when disease progresses .
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The wireless web test measures battery life by wirelessly browsing 25 popular websites with display brightness set to 8 clicks from bottom. Testing conducted by Apple in May 2022 using preproduction MacBook Air systems with Apple M2, 8-core CPU, 8-core GPU, 8GB of RAM, and 256GB SSD. Testing conducted by Apple in October 2020 using preproduction MacBook Air systems with Apple M1 chip and 8-core GPU, configured with 8GB of RAM and 512GB SSD. Connie Fisher was selected by public voting as the winner of the show. In early 2007, Fisher suffered from a heavy cold that prevented her from performing for two weeks.
Kerstin Anderson played Maria, with Ben Davis as Capt. von Trapp and Ashley Brown as Mother Abess. A UK tour produced by Bill Kenwright began in 2015 and toured into 2016. It was directed by Martin Connor and starred Lucy O'Byrne as Maria. A 2016 Australian tour of the Lloyd Webber production, directed by Sams, included stops in Sydney, Brisbane, Melbourne and Adelaide. The cast included Amy Lehpamer as Maria, Cameron Daddo as Captain Von Trapp, Marina Prior as Baroness Schraeder and Lorraine Bayly as Frau Schmidt.
CIA's 1960s OXCART Program and its use of U-2s are examples of collection innovations that have kept US leaders informed about adversaries' capabilities and intentions. Despite their success, however, use of these platforms carried significant risks and repercussions, including detection and even pilot loss, such as the downing of the U-2 flown by Francis Gary Powers in 1960. Ever-evolving research by the CIA led to the development concept of unmanned aerial vehicles as collection platforms. An innovative Agency program in the 1960s codenamed Aquiline was the very first to test this concept. While it never became operational, the concept proved invaluable as a forerunner to today's multi-capability UAVs.
One diagnostic clue that helps differentiate CKD from AKI is a gradual rise in serum creatinine as opposed to a sudden increase in the serum creatinine . In many people with CKD, previous kidney disease or other underlying diseases are already known. A significant number present with CKD of unknown cause. Kidney Care UK and The UK National Kidney Federation represent people with chronic kidney disease. The Renal Association represents Kidney physicians and works closely with the National Service Framework for kidney disease.
Additional tests may include nuclear medicine MAG3 scan to confirm blood flow and establish the differential function between the two kidneys. Dimercaptosuccinic acid scans are also used in kidney imaging; with both MAG3 and DMSA being used chelated with the radioactive element technetium-99. Chronic pyelonephritis with reduced kidney size and focal cortical thinning.
As an example, 37% of ESKD cases in African Americans can be attributed to high blood pressure, compared with 19% among Caucasians. Treatment efficacy also differs between racial groups. While lower socioeconomic status contributes to the number of people affected with CKD, differences in the number of people affected by CKD are still evident between Africans and Whites when controlling for environmental factors. Protein in the urine is regarded as an independent marker for worsening of kidney function and cardiovascular disease. Hence, British guidelines append the letter "P" to the stage of chronic kidney disease if protein loss is significant. Initial treatments may include medications to lower blood pressure, blood sugar, and cholesterol.
Risk factors include a family history of chronic kidney disease. Diagnosis is by blood tests to measure the estimated glomerular filtration rate , and a urine test to measure albumin. Ultrasound or kidney biopsy may be performed to determine the underlying cause.

Elicia MacKenzie won and played the role six times a week, while the runner-up in the TV show, Janna Polzin, played Maria twice a week. An Andrew Lloyd Webber production opened on November 15, 2006, at the London Palladium and ran until February 2009, produced by Live Nation's David Ian and Jeremy Sams. Following failed negotiations with Hollywood star Scarlett Johansson, the role of Maria was cast through a UK talent search reality TV show called How Do You Solve a Problem like Maria? The talent show was produced by Andrew Lloyd Webber and featured presenter/comedian Graham Norton and a judging panel of David Ian, John Barrowman and Zoe Tyler.